ECTS credits ECTS credits: 6
ECTS Hours Rules/Memories Hours of tutorials: 3 Expository Class: 33 Interactive Classroom: 15 Total: 51
Use languages Spanish (100%)
Type: Ordinary Degree Subject RD 1393/2007 - 822/2021
Departments: Zoology, Genetics and Physical Anthropology
Areas: Genetics
Center Faculty of Sciences
Call: First Semester
Teaching: Sin docencia (Extinguida)
Enrolment: No Matriculable
Knowledge and understanding of the principles of hereditary material (nature, expression, transmission, variation, manipulation and evolution) with a view to its application in animal production and in the conservation of diversity.
Lecture classes
Introduction: Genetics as the backbone of biological foundations. Application of genetic principles in basic research areas and applied to the areas of production, health and pharmaceuticals. History and areas of Genetics. (1 hour)
Block I: Foundations and laws of inheritance
Unit 1: Chromosomal basis of inheritance: The eukaryotic chromosome. Mitosis. Meiosis Karyotype. (2h)
Unit 2: Mendelian Genetics: Study of the inheritance of a character. Crossbreeding test. Inheritance of several characters. Chromosomal theory of inheritance: mendelism vs meiosis. Analysis of genealogies. (3h)
Unit 3: Extensions of mendelism: Variations in dominance. Multiple allelism. Lethal alleles. Pleiotropy. Gene interaction. Penentrance and expressiveness. (4h)
Unit 4: Heredity and sex: Determination of sex. Inheritance of genes located on sex chromosomes. Heredity influenced by sex. Inheritance limited by sex. Genetic basis of monogenic diseases: analysis in pedigrees (4h)
Block II: Diversity generation mechanisms and their applications
Unit 5: Ligation vs independent segregation. Crossover and recombination. Genetic maps. Linkage group. Coefficient of coincidence and genetic interference. Applications of genetic maps (4h)
Unit 6: Mutation: Types of mutations. Gene mutation. Mutation rate. Mutagens. The Ames test. Chromosomal mutations: Variations in chromosome number and structure. Clinical and production applications. (3h)
Unit 7: Gene expression and regulation. RNA transcription and maturation. Translation and genetic code. Regulation of gene expression in prokaryotes. Regulation of gene expression in eukaryotes. Developmental genetics. (4h)
Block III: Genetics of populations and their applications
Unit 8: Population Genetics: Mendelian population. Gene and genotypic frequencies. Estimators of genetic diversity. Hardy-Weinberg's law. Deviations from equilibrium: classified mating and consanguinity. Calculation of consanguinity in individuals and populations. Evolutionary agents. (4h)
Unit 9: Quantitative Genetics: Phenotypic variance. Continuous variation: genes and environment. Polygenic inheritance. Partition of the variance. Broad and strict heritability. Methods for estimating heritability. Response to selection. Genetic architecture of productive traits. (4h).
Problem seminars and tutorials
The three hours of problem seminars will be distributed after each of the main thematic blocks for solving model problems. The tutorials will be used to solve in small groups the doubts about the problem bulletins that the students have to solve on their own.
Laboratory practices
There are three practices to carry out in the matter:
1) Genetic study of qualitative characters. Study of the inheritance model of different characters using model organisms.
2) Karyotype analysis. It delves into the meaning of homologous chromosomes and diploid karyotype.
3) Population genetic analysis using computer programs and case studies
The first two will be held in the department's practice laboratory and the third in the faculty computer room. Each one has a specific script that the teacher in charge will present to the group of students.
Basic bibliography
- Brooker, RJ. 2012. “Genetics: analysis and principles”. McGraw-Hill.
- Brooker, RJ. 2018. “Genetics: analysis & principles. 6th Ed. McGraw Hill Education.
- Griffiths, AJF; Wessler, SR; Lewontin, RC; Carroll, SB. 2008. “Genética”. McGraw-Hill Interamericana.
- Griffiths, AJF; Wessler, SR; Carroll, SB; Doebley, J. 2015. “Introduction to Genetic Analysis”. W.H. Freeman and Company.
- Klug, W.S., Cummings, M.R., Spencer, C.A., y Palladino, M.A. 2013. Conceptos de genética. 10ª ed. Madrid: Pearson Educación.
- Hartl DL &Jones EW. 2009. “Genetics. Analysis of genes and genomes”. Jones and Bartlett Publishers.
- Pierce, BA. 2016. Genética: Un enfoque Conceptual. 5ª Ed. Editorial Médica Panamericana. Libro electrónico, Biblioteca USC: http://sfx.bugalicia.org/san/ebooksearch/
Complementary bibliography
- Benito Jiménez, C. 2002. “360 problemas de Genética: resueltos paso a paso”. Síntesis.
- Falconer, DS. 1996. “Introduction to Quantitative Genetics”. Longmans Green, Harlow.
- Klug, Cummings, M. R., Spencer, C. A., Palladino, M. A., & Killian, D. 2018. “Concepts of genetics”. 12th Ed. Pearson Education.
- Hartl DL. 2014. “Essential Genetics. A genomics perspective”. Jones and Bartlett Publishers.
- Hartl DL. 2020. Essentials Genetics and Genomics. 7th Ed. Jonet & Bartlett Learning.
- Hood, L; Goldberg, ML; Reynolds, AE; Silver, LM; Veres LC; Hartwell, LH. 2008. 3rd Ed. “Genetics: from genes to genomes” McGraw-Hill.
- Hartwell, Goldberg, M. L., Fischer, J. A., & Hood, L. E. 2017. “Genetics: from genes to genomes”. 6th Ed. McGraw-Hill.
- Mensua Fernández JL. 2003. “Genética: problemas y ejercicios resueltos”. Síntesis.
- Pierce BA. 2022. “Fundamentos de genética: conceptos y relaciones”. 5ª Ed. Editorial Médica Panamericana.
- Pierce BA. 2020. “Genetics: a conceptual approach”. 7th Ed. Macmillan International Higher Education.
Web resources
- Biotecnology and Genetic Engineering News (Noticias de divulgación relacionadas con la biotecnología y la Ingeniería Genética): http://www.genengnews.com
- MendelWeb: Introducción a la Genética Mendeliana: http://www.mendelweb.org/
- Página web del Instituto Nacional de Investigación del Genoma Humano (NHGRI): https://www.genome.gov/
- Pea Soup (Cruce virtual entre variedades de guisante y análisis de las descendencias): http://www.sonic.net/~nbs/projects/anthro201/exper/
- Problemas de mendelismo: http://www.biologia.arizona.edu/mendel/mendel.html
- The Cytogenetics Gallery (Cromosomas y mutaciones estructurales): http://www.pathology.washington.edu/galleries/cytogallery/main.php
-Genetic traits and diseases in humans and animals:
Online Catalog of Human Genes and Genetic Disorders: https://omim.org/
Online mendelian inheritance in animals: https://www.omia.org/home/
Basics
CB1-That students have demonstrated to possess and understand knowledge in an area of study that starts from the base of general secondary education, and is usually found at a level that, although it is supported by advanced textbooks, also includes some aspects that involve knowledge from the forefront of your field of study;
CB5-That students have developed those learning skills necessary to undertake further studies with a high degree of autonomy.
General
CG1.- Possess and understand fundamental knowledge about the organization and function of biological systems at the cellular and molecular levels.
CG7.- Ability to pose and solve questions and problems and interpret the results obtained in the field of Biochemistry and Molecular Biology.
Transversal
CT1 - Capacity for analysis and synthesis.
CT7 - Ability to solve problems.
Specific
CES6 - Understand the structure, organization, expression, regulation and evolution of genes in living organisms, as well as the molecular bases of genetic and epigenetic variation between individuals. Know the principles of the manipulation of nucleic acids, as well as the techniques that allow both the study of gene function, and the development of transgenic organisms with applications in biomedicine, industry, environment, agriculture, livestock, etc.
Lectures and practical classes
In the lectures, the specific contents of the program will be dealt with and for its development any material that helps and facilitates the understanding of the concepts that are dealt with (PowerPoint presentations, videos, animations, blackboard ...) will be used. The application of these contents will be done in interactive classes through problems, computer simulations or practical cases.
Problem seminars and short tutorials
For the different topics, students will have bulletins of problems of increasing complexity and related to the concepts covered; Basic models of problems will be solved in the classes of seminars, practices and tutorials.
Like the rest of the subjects of the Degree in Biochemistry, the evaluation system of the Genetics subject does not exclusively seek to determine what level of knowledge of the specific contents that a student has of the discipline. The evaluation method has also been designed to find out if the student has acquired some of the competences that appear in the memory of the Degree in Biochemistry and that are associated with this subject.
- In the exam the competences are evaluated: CB1, CB5, CG1, CG7, CT1, CT7, CES6
- In practice: CG7, CT1, CES6.
- In group tutoring: CG7, CT1, CES6
FIRST ENROLLMENT STUDENT
The evaluation system combines continuous evaluation (40% of the grade) and a final exam or test (60% remaining). In order to add the qualification of both evaluation modalities, the student must have a minimum mark of 4,5 out of 10 in the exam or final test. The continuous evaluation of each student will be done in person and will be based equally on the results obtained in controls, questionnaires or problem solving (15%) and attendance and use of practices (15%). The attendance and participation of her in the expository and interactive classes (10%) will also be considered. The final exam will be face-to-face.
REPEATER STUDENT
Continuous assessment and a final exam are also combined for their qualification. Continuous assessment will account for 20% of the final grade and will correspond to the score in this section that the student obtained in the course in which he / she enrolled for the first time. The remaining 80% will correspond to the final test grade. The methodology used will be the same as that applied to first-time students.
In cases of fraudulent completion of exercises or tests, the provisions of the Regulations for the validation of academic performance for two students and for the review of qualifications shall apply "
https://www.usc.gal/export9/sites/webinstitucional/gl/web/descargas/20_…".
Students who obtain an official exemption from face-to-face classes, the evaluation system will consist only of a final test that will account for 100% of the grade.
The Genetics subject is programmed considering a total of 150 hours of student work (6 ECTS credits) divided into:
PRESENTIAL HOURS (51 h):
- Lectures and interactive whiteboard classes: 36 hours (33 hours of lectures + 3 hours of problem seminars)
- Laboratory and computer practices: 12 hours
- Group tutorials: 3 hours
NON-PRESENTIAL HOURS (99 h):
- It is considered that the student has to dedicate about 66 hours of study and individual work; 30 hours of problem solving, answering questionnaires and solving practical cases. Finally, the student will dedicate a total of 3 hours to bibliographic review.
• Asking questions that may arise during the development of the lectures or interactive classes.
• Laboratory practices are a good time to refresh ideas or concepts, as well as to raise questions that may still remain.
• Make the problem sheets while advancing in the development of the concepts.
• Answer the questionnaires on case studies for later discussion in class and tutorials.
• Use tutorials to resolve doubts or questions.
• Read and consult sources of scientific information (databases, books, magazines, web pages, ...) that will enrich our perspective, since they understand much more casuistry than that dealt with during the course of the classes.
• Continuous study based on understanding concepts.
In cases of fraudulent completion of exercises or tests, the provisions of the Regulations for the validation of academic performance for two students and for the review of qualifications shall apply "
https://www.usc.gal/export9/sites/webinstitucional/gl/web/descargas/20_…".
M Carmen Bouza Fernandez
- Department
- Zoology, Genetics and Physical Anthropology
- Area
- Genetics
- mcarmen.bouza [at] usc.es
- Category
- Professor: University Lecturer
Paulino Martinez Portela
Coordinador/a- Department
- Zoology, Genetics and Physical Anthropology
- Area
- Genetics
- paulino.martinez [at] usc.es
- Category
- Professor: University Professor
Marina Pampín Iglesias
- Department
- Zoology, Genetics and Physical Anthropology
- Area
- Genetics
- marina.pampin.iglesias [at] usc.es
- Category
- Predoutoral USC_Campus Terra
Laila Al Soufi Novo
- Department
- Zoology, Genetics and Physical Anthropology
- Area
- Genetics
- laila.alsoufi [at] rai.usc.es
- Category
- Ministry Pre-doctoral Contract
Dorinda María Torres Sabino
- Department
- Zoology, Genetics and Physical Anthropology
- Area
- Genetics
- dorinda.torres.sabino [at] usc.es
- Category
- Xunta Pre-doctoral Contract
| Wednesday | ||
|---|---|---|
| 17:00-18:00 | Grupo /CLE_01 | 2P CLASSROOM 2 SECOND FLOOR |
| Thursday | ||
| 17:00-18:00 | Grupo /CLE_01 | 2P CLASSROOM 2 SECOND FLOOR |
| 01.17.2024 16:00-20:00 | Grupo /CLE_01 | 2P CLASSROOM 2 SECOND FLOOR |
| 01.17.2024 16:00-20:00 | Grupo /CLE_01 | 2P CLASSROOM 5 SECOND FLOOR |
| 06.17.2024 16:00-20:00 | Grupo /CLE_01 | 2P CLASSROOM 2 SECOND FLOOR |
| 06.17.2024 16:00-20:00 | Grupo /CLE_01 | 2P CLASSROOM 5 SECOND FLOOR |
| Teacher | Language |
|---|---|
| Bouza Fernandez, M Carmen | Spanish |
| MARTINEZ PORTELA, PAULINO | Spanish |
| Teacher | Language |
|---|---|
| Al Soufi Novo, Laila | Spanish |
| MARTINEZ PORTELA, PAULINO | Spanish |
| Torres Sabino, Dorinda María | Spanish |
| Teacher | Language |
|---|---|
| MARTINEZ PORTELA, PAULINO | Spanish |
| Pampín Iglesias, Marina | Spanish |
| Torres Sabino, Dorinda María | Spanish |
| Teacher | Language |
|---|---|
| MARTINEZ PORTELA, PAULINO | Spanish |
| Pampín Iglesias, Marina | Spanish |
| Teacher | Language |
|---|---|
| Al Soufi Novo, Laila | Spanish |
| MARTINEZ PORTELA, PAULINO | Spanish |
| Teacher | Language |
|---|---|
| Al Soufi Novo, Laila | Spanish |
| Bouza Fernandez, M Carmen | Spanish |
| MARTINEZ PORTELA, PAULINO | Spanish |
| Teacher | Language |
|---|---|
| MARTINEZ PORTELA, PAULINO | Spanish |
| Teacher | Language |
|---|---|
| MARTINEZ PORTELA, PAULINO | Spanish |
| Teacher | Language |
|---|---|
| MARTINEZ PORTELA, PAULINO | Spanish |
| Teacher | Language |
|---|---|
| Bouza Fernandez, M Carmen | Spanish |
| Teacher | Language |
|---|---|
| Bouza Fernandez, M Carmen | Spanish |